This test evaluates multiple genes that affect how your body metabolises carbohydrates, fats, and proteins, as well as how you respond to caffeine. You’ll gain insight into your ideal macronutrient balance, how efficiently your body uses energy, your muscle development potential, and whether you should moderate your caffeine intake.

The MacroMatch DNA Test analyses key genes in four major areas: 

MacroMatch Test for carbohydrate metabolism, insulin sensitivity and glucose regulation

The MacroMatch DNA Test analyses how your body processes carbohydrates and regulates blood glucose levels — functions that are largely influenced by your genetics. Variants in the following genes can affect how carbohydrates are converted into energy and stored, which in turn impacts your risk of insulin resistance, type 2 diabetes, and weight gain.

PPARG (Peroxisome Proliferator-Activated Receptor Gamma)

PPARG plays a central role in fat and carbohydrate metabolism, as well as insulin sensitivity. It regulates how the body stores fat and how cells respond to insulin. Certain variants of this gene are associated with a decreased ability to respond to insulin effectively, increasing susceptibility to insulin resistance, metabolic syndrome, and obesity. Individuals with these variants may benefit from lower carbohydrate diets and increased physical activity to maintain healthy blood sugar levels.

KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11).

This gene is responsible for encoding a key protein involved in insulin secretion from pancreatic beta cells. Genetic variants in KCNJ11 can impair insulin release, reducing the body’s ability to regulate blood sugar effectively. This can contribute to elevated fasting glucose and an increased risk of type 2 diabetes. Understanding your KCNJ11 profile can help tailor carbohydrate intake and glycaemic load to support stable energy and glucose control.

TCF7L2 (Transcription Factor 7-Like 2).

Widely regarded as one of the strongest genetic predictors of type 2 diabetes, TCF7L2 influences how the body interprets insulin signals and manages glucose. Certain variants can alter the function of pancreatic beta cells and interfere with insulin production, leading to poor carbohydrate processing and heightened diabetes risk. Individuals with risk alleles may benefit from early interventions such as dietary modifications, increased fibre intake, and consistent glucose monitoring.

We also offer the Carbohydrate Metabolism DNA Tests as an individual product — you can find more information by clicking on the test name.

MacroMatch Test for lipid metabolism, Fat breakdown and cardiovascular health

Genetic differences can significantly impact how your body processes fats, regulates cholesterol, and stores triglycerides. The MacroMatch DNA Test analyses markers that can reveal your predisposition to conditions such as high cholesterol, heart disease, or metabolic syndrome—even if you follow a healthy diet.

APOA1 (Apolipoprotein A1)

APOA1 is crucial for the formation of HDL cholesterol, commonly referred to as “good” cholesterol. It facilitates reverse cholesterol transport—removing excess cholesterol from arteries and delivering it to the liver for elimination. Variants that reduce APOA1 expression can lead to lower HDL levels, increasing the risk of plaque buildup in the arteries and cardiovascular disease.

APOC3 (Apolipoprotein C3)

This gene regulates the breakdown of triglycerides in the bloodstream. Unfavourable variants in APOC3 may slow down fat clearance, promoting fat storage and elevating triglyceride levels. This is a major contributor to the development of insulin resistance and metabolic syndrome. Individuals with these variants may benefit from reduced intake of saturated fats and refined sugars.

CETP (Cholesteryl Ester Transfer Protein)

CETP manages the exchange of cholesterol between HDL and LDL particles. Some genetic variants result in decreased HDL and increased LDL cholesterol levels, creating an unfavourable lipid profile. These individuals may face higher cardiovascular risk even with a balanced diet, highlighting the need for personalised interventions based on genetic makeup.

LDLR (Low-Density Lipoprotein Receptor)

The LDLR gene encodes a receptor responsible for removing LDL (“bad” cholesterol) from the bloodstream. Mutations in LDLR can reduce the clearance of LDL particles, leading to persistently high cholesterol and an elevated risk of atherosclerosis. In some cases, individuals may have a genetic condition known as familial hypercholesterolemia, which requires medical management beyond dietary changes.

We also offer the Lipid Metabolism DNA Tests as an individual product — you can find more information by clicking on the test name.

MacroMatch test for protein metabolism, muscle growth, repair, and recovery

Your body’s ability to synthesise and utilise protein influences muscle development, performance, and recovery. The MacroMatch DNA Test analyses key genes to help determine how your body builds lean mass, responds to exercise, and regulates overall metabolism.

ACTN3 (Alpha-Actinin-3)

Known as the “speed gene,” ACTN3 is linked to muscle fibre composition. One variant is associated with fast-twitch muscle fibres ideal for sprinting and strength sports, while the absence of functional ACTN3 may favour endurance performance. Understanding your ACTN3 type can help inform your training focus and recovery strategy.

FTO (Fat Mass and Obesity-Associated Gene)

FTO influences appetite control, energy expenditure, and body composition. Certain variants are associated with increased hunger, reduced satiety, and a tendency to accumulate fat over muscle. These individuals may find it more difficult to retain lean muscle mass, especially during caloric restriction. Personalised dietary strategies may help overcome this genetic predisposition.

MTHFR (Methylenetetrahydrofolate Reductase)

This gene plays a key role in the metabolism of folate and homocysteine, both critical for DNA synthesis, amino acid processing, and recovery. Variants in MTHFR may reduce enzyme activity, potentially leading to increased inflammation and slower recovery post-exercise. Supplementation with active forms of folate and optimising protein intake can be especially beneficial for those with reduced MTHFR function.

MacroMatch test for caffeine metabolism, sensitivity and cardiovascular impact

Caffeine affects the body differently depending on your genetic makeup. Some people experience energy and alertness with moderate consumption, while others may suffer from side effects like anxiety, poor sleep, or increased blood pressure due to slow caffeine clearance.

CYP1A2 (Cytochrome P450 1A2)

CYP1A2 is the primary liver enzyme responsible for breaking down caffeine. Individuals with a “fast metaboliser” genotype can typically tolerate and benefit from moderate caffeine intake. However, those with the “slow metaboliser” variant break down caffeine more slowly, which can lead to prolonged stimulation, sleep disturbances, anxiety, and a higher risk of hypertension. Knowing your caffeine sensitivity allows you to personalise your intake for optimal mental performance and cardiovascular safety.

We also offer the Caffeine Metabolism DNA Tests as an individual product — you can find more information by clicking on the test name.