Hereditary Breast and Ovarian Cancer Risk Assessment Test
Developed by geneType, a world leader in Genetic Risk Assessment, this test allows you to predict your chances of developing breast and ovarian cancer based on all of your risk factors and not just your genes.
The test looks at 13 genes associated with these cancers. If you are negative for a mutation in one of the 13 genes, you will still get a risk score for your chance of getting either cancer based on polygenic and clinical risk factors. You can then take the appropriate risk reduction measures available.
Take a proactive approach to your health. Be in the know with geneType!
Free Delivery
Results in 4-5 weeks
From $449
- Must be 30 years or older to order this test and cannot have had breast or ovarian cancer previously
- Genes include: ATM, BARD1, BRCA1, BRCA2, BRIP1, CHEK2, NF1, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53
- Risk scores caluclated on your polygenic risk and clinical risk factors
- Be empowered to make informed decisions with your doctor
- Ordered by a telehealth physician using an online portal
- This test is not available to NY state residents
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How it Works
Key Features of the Genetic Predisposition Test
What is the Comprehensive Hereditary Breast and Ovarian (HBOC) test?
The 13 Gene Comprehensive hereditary breast and ovarian (HBOC) test is a proactive genetic-integrated test that allows healthy adults without a strong family history of either cancer to learn about their risk. This test looks at an adults' DNA (both rare and common genetic variants) as well as their clinical risk factors.
First we will test you for rare variants in 13 genes. If those 13 genes do not reveal any mutations then we will test you for more common risk variants. Your final risk score will be a combination of your genetic risk plus your clinical risk.
Did you know that only 1 in 200 women will come back positive for a known variant (also known as a pathogenic variant or mutation)?!
What is a geneType risk score?
geneType risk assessment predicts your personal risk of disease. When you go to the doctor, they usually ask about your family history of disease, and they take a look at your blood pressure, weight and look at your bloodwork. All of that is part of a traditional risk assessment.
Problem: But, many people develop disease like cancer “out of the blue,” and our doctors didn’t suspect they were at risk!
Solution: geneType can identify more adults that may be at-risk of disease so you and your doctor may be able to take action to reduce that risk!
1 in 5 women will have a risk score that puts her at increased risk of developing breast cancer!
How does geneType work?
geneType looks at more risk factors – including ones that may not be routinely examined by your doctor. Risk factors are different from disease to disease, but examples include: polygenic risk, BMI, family history and breast density status.
Risk factors explained:
Polygenic risk: This test looks at low levels of genetic predisposition called polygenic risk. You were born with this risk, and you cannot change this risk. But it’s important to know that it is only ONE of MANY risk factors that can help predict your risk of developing disease.
BMI: your body mass index is an important risk factor that is associated with many diseases from cancers to cardiovascular diseases to diabetes. This is a factor you can change.
Family History: You cannot change your family history. But sometimes you don’t know your family history well, or at all. This is why it’s important to consider additional risk factors and not just rely on family history.
Breast Density Status: The amount of tissue in a mammogram image that makes it harder to see a potential tumor. If you have had a mammogram, you will have gotten a breast density notification letter. There are four general BI-RADS categories to define breast density status.
• Not as dense = entirely fatty & scattered fibroglandular density
• More dense = heterogeneously dense & extremely dense.
Learn more about breast density and the notification letter you received from your last mammogram using this link.
Technology:
geneType test is based on years of scientific data. Scientists looked at thousands of people with disease compared to thousands of people without disease to identify differences. Those differences are risk factors that we can quantify. This risk assessment looks at the most impactful risk factors associated with disease and combines them together to predict your chances of getting that disease.
Clinical Grade Risk-Assessment at your Fingertips!
Unlike genetic-hobbyist tests, geneType is clinician-ordered test that delivers a comprehensive overview of your predisposition to breast and ovarian cancer by sequencing your DNA and combining your genetic risk with cyour clinical risk factors.
The test is available to eligible patients who are 30 years or older and have never been diagnosed with breast or ovarian cancer. The assessment focuses specifically on evaluating the genetic and clinical risk for these cancers.
What are the benefits?
Picture an iceberg. The risks that you and your doctor usually talk about are the ones you can see. Have you ever thought about the ones that you can’t see (below the water)? One of the risk factors that geneType looks at, called polygenic risk, is a risk factor that you can’t see. But everyone has a polygenic risk.
By getting your risk assessment through geneType, you get a better picture of your overall risk, by looking at “common” risk factors like family history and BMI, but also looking at “hidden” risk like polygenic risk.
When you have a better understanding of your risk, you and your doctor can make more informed decisions about screening for certain diseases, risk-reducing medications and even changes to lifestyle habits to reduce your risk.
You may even learn about a disease risk that you weren’t even aware of!
Who is geneType, the world leader in Genetic Risk Assessment?
GeneType is part of Genetic Technologies Limited, a pioneer in the field of clinical genetics that has spent the past 20 years decoding the genome and unlocking its value for human health.
Under our geneType product series, our clinicians, scientists and technicians are working to develop the next generation of integrated predictive genetic testing and assessment tools – empowering physicians and patients to proactively manage health.
The company has also evolved into a world leader in Genetic Risk Assessment. Our brand geneType offers integrated risk testing for a range of serious conditions. GeneType disease prediction can allow for personalized preventive health plans to manage risk. Early detection can save lives!
For more information visit our website https://genetype.com/
FAQs
Your DNA is made up of 3 billion base paired nucleotides. The four main nucleotides A, G, C, & T (known as adenine, guanine, cytosine and thymine) are strung together in a unique code that contains all the information necessary to make you, YOU! When we compare your DNA to your neighbors DNA, it is 99.9% identical. The 0.1% difference are due to single nucleotide polymorphisms (SNP). These SNP are common genetic variations that are normal. They make you unique. Everyone has a different combination of these SNP. When scientists started looking at large groups of people with a certain disease compared to people without that disease, they noticed different patterns of SNP. Polygenic risk is a specific combination of SNP that are associated with a disease (like breast cancer) or a trait (like height).
Everyone has a polygenic risk that can define their predisposition to a disease, or trait. It is like a “baseline” risk you are born with. But it remember, disease develops due to the combination of many risk factors and polygenic risk is only one risk factor out of many. Polygenic risk alone will not determine your fate.
Most women don’t have a significant family history of breast or ovarian cancer to qualify them for HBOC (hereditary breast and ovarian cancer gene panel testing) covered by insurance. But, a small fraction of women (less than 1%) may still be carriers of a mutation (also known as a pathogenic variant) that predisposes them to a very high risk of developing breast or ovarian cancer. The 13 gene comprehensive HBOC geneType test will look for those very rare mutations, and then if we don’t find any mutations, the patient will get a report that looks at her risk of developing those diseases based on her clinical and polygenic risk.
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